This proposal presents an innovative teaching framework that seamlessly integrates diverse skill training, hands-on project experience, and direct career preparation. The course transforms novices with zero engineering background into experts in biomedical instrument design through a unique two-tiered project system. Students will be guided to build their own ECG device before tackling complex group projects on advanced biomedical challenges. The key innovation lies in its direct link to career readiness, actively guiding students to translate their extensive project work into useful skills and powerful CV. This model ensures students gain deep technical proficiency and are fully equipped for future academic and professional success.